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Evolutionary Coupling Analysis

Predicted and experimental contacts

Interactive contact map

Secondary structure from ECs

Known pdb structures

pdb chain
2l9r A

EC score distribution and threshold

Top ECs

Rank Residue 1 Amino acid 1 Residue 2 Amino acid 2 EC score
1 140 E 175 R 1.17
2 143 F 179 T 1.12
3 157 L 168 V 1.12
4 3 R 7 P 1.11
5 142 K 153 E 0.96
6 151 A 177 Y 0.93
7 3 R 11 E 0.90
8 141 R 145 H 0.85
9 9 P 13 K 0.85
10 57 E 61 E 0.85
11 5 P 10 G 0.84
12 169 K 177 Y 0.84
13 3 R 8 R 0.83
14 61 E 65 G 0.82
15 156 H 160 N 0.82
16 61 E 67 S 0.80
17 154 R 165 E 0.79
18 131 F 163 L 0.78
19 59 E 63 E 0.77
20 179 T 183 Q 0.77
21 138 E 160 N 0.77
22 154 R 169 K 0.77
23 63 E 67 S 0.76
24 102 Y 106 S 0.76
25 8 R 12 A 0.75
26 127 S 133 H 0.75
27 4 V 9 P 0.75
28 8 R 13 K 0.74
29 4 V 8 R 0.74
30 137 I 141 R 0.73
31 99 L 103 L 0.73
32 127 S 170 I 0.72
33 64 G 69 A 0.72
34 75 Q 79 G 0.72
35 142 K 146 Q 0.72
36 130 A 136 V 0.71
37 153 E 166 T 0.71
38 126 R 130 A 0.71
39 177 Y 181 R 0.71
40 3 R 9 P 0.71
41 60 P 66 R 0.70
42 64 G 68 R 0.70
43 68 R 72 Q 0.70
44 173 Q 180 K 0.70
45 5 P 15 E 0.69
46 76 L 85 E 0.69
47 133 H 137 I 0.69
48 163 L 167 Q 0.69
49 6 E 10 G 0.69
50 155 A 159 K 0.69
51 59 E 66 R 0.69
52 80 P 86 E 0.68
53 131 F 148 Y 0.68
54 62 P 67 S 0.68
55 5 P 9 P 0.68
56 3 R 12 A 0.68
57 131 F 166 T 0.67
58 58 P 64 G 0.67
59 96 E 100 G 0.66
60 63 E 68 R 0.66
61 146 Q 153 E 0.66
62 83 A 88 E 0.66
63 7 P 15 E 0.66
64 59 E 70 G 0.66
65 64 G 71 A 0.66
66 4 V 12 A 0.66
67 65 G 70 G 0.66
68 97 R 103 L 0.66
69 95 P 100 G 0.65
70 190 D 232 A 0.65
71 146 Q 150 S 0.65
72 183 Q 187 E 0.65
73 5 P 12 A 0.65
74 4 V 14 A 0.65

Alignment robustness analysis

First most common residue correlation

Second most common residue correlation

Robustness